This is the history of 300 years of chemistry at Trinity College Dublin, from its beginnings in the early years of the eighteenth century to the present day. The narrative also serves as a history of the development of chemistry as a science and the part played by Trinity in this development. The first chemistry lecturer in the College was appointed in 1711 whose job was to teach chemistry to medical students, and since that humble beginning over 300 years ago chemistry in Trinity has blossomed into a major interdisciplinary subject with a primary input into other areas such as biochemistry, genetics, immunology and materials science. Trinity has also played its part in the development of hugely important industrial concerns such as the enormously valuable pharmaceutical industry. As well as chronicling these advancements, the book also focuses on the individual people who worked on chemistry in Trinity over the past three centuries, and tells the stories of the many brilliant, idiosyncratic, and clever personalities who were responsible for the well-being of chemistry within our walls. It is hoped that the many chemistry graduates of Trinity will find pleasure in these pages.